Meta-analysis of the effect of extending the interval after long-course chemoradiotherapy before surgery in locally advanced rectal cancer.
Éanna J RyanD P O'SullivanMichael E KellyA Z SyedP C NearyP R O'ConnellD O KavanaghD C WinterJ M O'RiordanPublished in: The British journal of surgery (2019)
A minimum 8-week interval from the end of nCRT to TME increases pCR and downstaging rates, and improves recurrence-free survival without compromising surgical morbidity.