Declining antibody levels after hepatitis B vaccination in Down syndrome: A need for booster vaccination?
Noortje B EijsvoogelMirjam I HollegienVinus L A BokArda G Derksen LubsenFelix P J DikkenSander A C A P LeendersArjan PijningErica PostMarek WojciechowskiMirrian HilbinkEsther de VriesPublished in: Journal of medical virology (2017)
We determined the anti-HBs titer in 227 children of all ages with Down syndrome (DS). Only 48.1% (95%CI: 35.1-61.3) of the DS children aged 7-10 years and 31.9% (95%CI: 22.1-43.6) of the DS children aged >10 years had a protective anti-HBs titer (≥10 IU/L). The geometric mean anti-HBs titer was significantly lower in the DS children; this suggests booster vaccination for HBV may be needed.
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