Effects of therapeutic hypothermia on death among asphyxiated neonates with hypoxic-ischemic encephalopathy: A systematic review and meta-analysis of randomized control trials.
Biruk Beletew AbateMelaku BimerewBereket GebremichaelAyelign Mengesha KassieMesfinWudu KassawTeshome GebremeskelWubet Alebachew BayihPublished in: PloS one (2021)
Therapeutic hypothermia reduces the risk of death in neonates with moderate to severe hypoxic-ischemic encephalopathy. Both selective head cooling and whole-body cooling method are effective in reducing the mortality of infants with this condition. Moreover, low income countries benefit the most from the therapy. Therefore, health professionals should consider offering therapeutic hypothermia as part of routine clinical care to newborns with hypoxic-ischemic encephalopathy especially in low-income countries.
Keyphrases
- early onset
- cardiac arrest
- brain injury
- low birth weight
- healthcare
- open label
- pregnant women
- double blind
- preterm infants
- risk factors
- cardiovascular events
- type diabetes
- clinical trial
- coronary artery disease
- placebo controlled
- bone marrow
- mesenchymal stem cells
- chronic pain
- cord blood
- phase iii
- optic nerve
- drug induced