Telomere length dynamics over 10-years and related outcomes in patients with COPD.
A Elizabeth Córdoba-LanúsS Cazorla-RiveroM A García-BelloD MayatoF GonzalvoJ Ayra-PlasenciaB CelliC CasanovaPublished in: Respiratory research (2021)
This prospective study shows an association between accelerated telomere shortening and progressive worsening of pulmonary gas exchange, lung hyperinflation and extrapulmonary affection in COPD patients. Moreover, persistently shorter telomeres over this observation time increase the risk for all-cause mortality.
Keyphrases
- chronic obstructive pulmonary disease
- end stage renal disease
- lung function
- ejection fraction
- newly diagnosed
- chronic kidney disease
- multiple sclerosis
- pulmonary hypertension
- peritoneal dialysis
- prognostic factors
- type diabetes
- air pollution
- patient reported outcomes
- skeletal muscle
- insulin resistance
- patient reported