Germline genetic variants associated with somatic TMPRSS2:ERG fusion status in prostate cancer: a genome-wide association study.

Chaoran Ma Xiaoyu Wang James Y Dai Constance Turman Peter Kraft Konrad H Stopsack Massimo Loda Andreas Pettersson Lorelei A Mucci Janet L Stanford Kathryn L Penney

Published in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2023)

Our findings suggest that tumors with the TMPRSS2:ERG fusion exhibit a different germline genetic etiology compared to fusion negative cases.

Keyphrases

prostate cancer
genome wide association study
dna repair
radical prostatectomy
copy number