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Activation of the prostaglandin E2 EP2 receptor attenuates renal fibrosis in unilateral ureteral obstructed mice and human kidney slices.

Michael Schou JensenHenricus A M MutsaersStine Julie TingskovMichael ChristensenMia Gebauer MadsenPeter OlingaTae-Hwan KwonRikke Nørregaard
Published in: Acta physiologica (Oxford, England) (2019)
In conclusion, this study demonstrates that stimulation of the EP2 receptor effectively mitigates renal fibrogenesis in various fibrosis models. These findings warrant further research into the clinical application of butaprost, or other EP2 agonists, for the inhibition of renal fibrosis.
Keyphrases
  • endothelial cells
  • liver fibrosis
  • radiation therapy
  • adipose tissue
  • skeletal muscle
  • insulin resistance