Transcriptomics of biopsies identifies novel genes and pathways linked to neutrophilic inflammation in severe asthma.
Stephany Sánchez-OvandoJodie Louise SimpsonDaniel BarkerKatherine Joanne BainesPeter A B WarkPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2021)
NA features a distinct transcriptomic profile with seven pathways enriched in NA compared to EA, PGA and HC. All those with severe asthma had significant enrichment for SUMOylation, basal cell carcinoma signalling and Wnt/β-catenin pathways compared to HC, despite high-dose inhaled corticosteroids. These findings contribute to the understanding of mechanistic pathways in endobronchial biopsies associated with NA and identify potential novel treatment targets for severe asthma.