Neurological manifestations of hereditary transthyretin amyloidosis: a focus on diagnostic delays.

Michelle C Kaku Shivkumar Bhadola John L Berk Vaishali Sanchorawala Lawreen H Connors K H Vincent Lau

Published in: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis (2022)

Our study found higher rates of polyneuropathy by examination than patient-reported symptoms, especially among those with V122I TTR amyloidosis, signalling asymptomatic polyneuropathy. Our findings suggest the need for routine neurological examinations and other testing for genetic carriers to achieve earlier identification of active disease state.

Keyphrases

patient reported
multiple myeloma
genome wide
clinical practice
copy number
dna methylation
sleep quality
physical activity