Treatment of Cushing's Disease with Pituitary-Targeting Seliciclib.
Ning Ai LiuAnat Ben-ShlomoJohn D CarmichaelChristina WangRonald S SwerdloffAnthony P HeaneyGarni BarkhoudarianDaniel KellyMazen NoureddinLin LuManish DesaiYana StolyarovKevin YuenAdam N MamelakJames MirochaMourad TighiouartShlomo MelmedPublished in: The Journal of clinical endocrinology and metabolism (2022)
Seliciclib may directly target pituitary corticotrophs in CD and reverse hypercortisolism. Potential liver toxicity of seliciclib resolves with treatment withdrawal. The lowest effective dose requires further determination.
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