ALDH1A inhibition sensitizes colon cancer cells to chemotherapy.

Zuzana KozovskaA PatsaliasV BajzikE DurinikovaL DemkovaS JargasovaB SmolkovaJ PlavaL KucerovaM Matuskova

Published in: BMC cancer (2018)

This research, verifies the significance of the ALDH1A isoforms in multidrug resistance of human colorectal cancer cells and its potential as a cancer stem cell marker. This provides the basis for the development of new approaches regarding the treatment of patients with colorectal adenocarcinoma and potentially the treatment of other tumor malignancies.

Keyphrases

squamous cell carcinoma
cancer stem cells
locally advanced
combination therapy
radiation therapy