Photochemistry and in vitro anticancer activity of Pt(IV)Re(I) conjugates.

Zhouyang HuangA Paden KingJames LovettBarry LaiJoshua J Woods Hugh H Harris Justin J Wilson

Published in: Chemical communications (Cambridge, England) (2021)

The photophysical and photochemical properties of two Pt(IV)Re(I) conjugates were studied via both experimental and computational methods. Both conjugates exhibit modest photocytotoxicity against ovarian cancer cells. X-ray fluorescence microscopy showed that Pt and Re colocalize in cells whether they had been irradiated or not. This work demonstrates the potential of photoactivated multilimetallic agents for combating cancer.

Keyphrases

cancer therapy
high resolution
single molecule
induced apoptosis
papillary thyroid
cell cycle arrest
squamous cell
drug delivery
high throughput
high speed
magnetic resonance imaging
oxidative stress
computed tomography
cell death
risk assessment
endoplasmic reticulum stress
dual energy
pi k akt
quantum dots