Coagulation disorders in patients with severe hemophagocytic lymphohistiocytosis.

Sandrine ValadeBérangère S JolyAgnès VeyradierJehane FadlallahLara ZafraniVirginie LemialeAmélie LaunoisAlain StepanianLionel GalicierClaire FieschiAdrien MirouseJean Jacques TudesqAnne-Claire LepretreElie AzoulayMichael DarmonEric Mariotte

Published in: PloS one (2021)

Hyperfibrinolysis may be the primary mechanism responsible for hypofibrinogenemia and may also participate in ADAMTS13 degradation. Targeting the plasmin system appears as a promising approach in severe HLH-related coagulation disorders.

Keyphrases

early onset
drug induced
cancer therapy