Extracellular vesicles from adipose-derived stem cells promote microglia M2 polarization and neurological recovery in a mouse model of transient middle cerebral artery occlusion.

Xiaowen HuJiaji PanYongfang LiYixu JiangHaoran ZhengRubing ShiQi ZhangChang LiuHengli TianZhijun ZhangYaohui TangGuo-Yuan YangYongting Wang

Published in: Stem cell research & therapy (2022)

In summary, ADSC-EVs reduced ischemic brain injury, which was associated with the regulation of microglial polarization. miRNAs in ADSC-EVs partly contributed to their function in regulating microglial polarization by targeting PTEN and STAT1.

Keyphrases

brain injury
cerebral ischemia
middle cerebral artery
subarachnoid hemorrhage
inflammatory response
mouse model
neuropathic pain
lipopolysaccharide induced
cell proliferation
lps induced
internal carotid artery
blood brain barrier
spinal cord
pi k akt
spinal cord injury
oxidative stress