Frequency and Genomic Aspects of Intrinsic Resistance to Vismodegib in Locally Advanced Basal Cell Carcinoma.
Andrey A YurchenkoOltin Tiberiu PopMeriem IghilahrizIsmael PadioleauFatemeh RajabiHayley J SharpeNicolas PoulalhonBrigitte DrenoAmir KhammariMarc DelordAntonio AlbertiNadem SoufirMaxime BattistellaSamia MourahFanny BouquetAriel SavinaAndrej BesseMax Mendez-LopezFlorent GrangeSandrine MonestierLaurent MortierNicolas MeyerCaroline DutriauxCaroline RobertPhilippe SaiagFlorian HermsJerome LambertFrederic J de SauvageNicolas DumazLukas FlatzNicole Basset-SeguinSergey I NikolaevPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
IR to vismodegib is a rare event in laBCC. IR-BCCs frequently harbor resistance mutations in the Hh pathway, but also are characterized by hyperactivation of the HIPPO-YAP and WNT pathways.