Association of SOX11 Polymorphisms in distal 3'UTR with Susceptibility for Schizophrenia.

Cheng-Peng SunDong SunZhi-Lin LuanXin DaiXu BieWen-Hua MingXiao-Wan SunXiao-Xiao HuoTian-Lan LuDai Zhang

Published in: Journal of clinical laboratory analysis (2020)

Our results suggest SOX11 as a susceptibility gene for schizophrenia, and SOX11 polymorphisms and haplotypes in the distal 3'UTR of the gene might modulate transcriptional activity by serving as cis-regulatory elements and recruiting transcriptional activators or repressors. Also, these SNPs may potentiate as diagnostic markers for the disease.

Keyphrases

transcription factor
genome wide identification
genome wide
bipolar disorder
stem cells
minimally invasive
copy number
gene expression
dna methylation
heat shock
oxidative stress