Validation of the C-X-C chemokine receptor 3 (CXCR3) as a target for PET imaging of T cell activation.
Sebastian MartinLennard WendlingerBéatrice ZittiMehdi HichamViktoriia PostupalenkoLéo MarxGreta Giordano-AttianeseElisabetta CribioliMelita IrvingAlexandra LitvinenkoRadmila FaizovaDavid ViertlMargret SchotteliusPublished in: EJNMMI research (2024)
T cell numbers in tumors was challenging due to secondary antibody-related effects. Nonetheless, CXCR3 remains a promising target for imaging T cell activation, with anticipated improvements in sensitivity using alternative tracers with high affinities and favorable pharmacokinetics.