Seizure-onset regions demonstrate high inward directed connectivity during resting-state: An SEEG study in focal epilepsy.
Saramati NarasimhanKeshav B KundasseryKanupriya GuptaGraham W JohnsonKristin E WillsSarah E GoodaleKevin HaasJohn D RolstonRobert P NaftelVictoria L MorganBenoit M DawantHernán F J GonzálezDario J EnglotPublished in: Epilepsia (2020)
Directed connectivity measures may help identify epileptogenic networks without requiring ictal recordings. Greater inward but not outward connectivity in ictogenic regions at rest may represent broad inhibitory input to prevent seizure generation.