Multi-trait association studies discover pleiotropic loci between Alzheimer's disease and cardiometabolic traits.

William P BoneKatherine M SiewertAnupama JhaDerek KlarinScott M Damrauernull nullKyong-Mi ChangPhilip S TsaoThemistocles L AssimesMarylyn D RitchieBenjamin F Voight

Published in: Alzheimer's research & therapy (2021)

Our results support a complex genetic relationship between AD and these cardiometabolic traits, and the candidate causal genes identified suggest that blood pressure and immune response play a role in the pleiotropy between these traits.

Keyphrases

genome wide
dna methylation
blood pressure
immune response
copy number
gene expression
heart rate
dendritic cells
metabolic syndrome
adipose tissue
insulin resistance
inflammatory response
genome wide association