[Sesamin Preconditioning Attenuates Myocardial Ischemia Reperfusion Injury in Rats Through Activation of Akt/eNOS Signaling Pathway].

Meng-qiu ZhaoPeng-cheng TuYou-nan RenShan-jun TaoShu-guo Zheng

Published in: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials (2018)

Pretreatment with sesamin effectively ameliorated myocardial ischemia reperfusion injury in rats, and the mechanism might be related to enhancing its antioxidant capacity and the activation of Akt / eNOS signaling pathway and subsequent increase of NO synthesis and suppression of cardiac myocyte apoptosis.

Keyphrases

signaling pathway
pi k akt
cell cycle arrest
left ventricular
cell proliferation
induced apoptosis
epithelial mesenchymal transition
oxidative stress
nitric oxide synthase
endothelial cells
cell death
nitric oxide
atrial fibrillation
drug induced