Selective thyroid hormone receptor beta agonist, GC-1, is capable to reduce growth of colorectal tumor in syngeneic mouse models.

Katayoun Pourvali Ghazaleh Shimi Arman Ghorbani Azam ShakeryFarshad Hosseini ShiraziHamid Zand

Published in: Journal of receptor and signal transduction research (2022)

Our results showed that specific activation of TRβ by GC-1 had negative effect on tumor growth and restored its gene expression in tumors of CRC mice model.

Keyphrases

gene expression
mouse model
gas chromatography
dna methylation
high fat diet induced
mass spectrometry
adipose tissue
metabolic syndrome
high resolution
insulin resistance