Comparison of three dosing intervals for the primary vaccination of the SARS-CoV-2 mRNA Vaccine (BNT162b2) on magnitude, neutralization capacity and durability of the humoral immune response in health care workers: A prospective cohort study.

Darryl P LeongAli ZhangJessica A BreznikRumi ClareAngela HuynhMaha MushtahaSumathy RangarajanHannah StaceyPaul Y KimMark LoebJudah A DenburgDominik MertzZain ChaglaIshac NazyMatthew S MillerDawn M E Bowdish MyLinh Duong

Published in: PloS one (2023)

This is the first comprehensive study to compare 3 dosing intervals for the primary vaccination of BNT162b2 mRNA COVID-19 vaccine implemented in the real world. These findings suggest that delaying the second dose beyond 42 days can potentiate and prolong the humoral response against ancestral and Beta variants of SARS-CoV-2 up to 9 months post-vaccination.

Keyphrases

sars cov
immune response
respiratory syndrome coronavirus
coronavirus disease
toll like receptor
gene expression
copy number
dna methylation
inflammatory response