Early Onset Intrahepatic Cholangiocarcinoma: Clinical Characteristics, Oncological Outcomes, and Genomic/Transcriptomic Features.

Diamantis I TsilimigrasXu HanAlfredo GuglielmiLuca AldrighettiMatthew WeissTodd W BauerSorin AlexandrescuGeorge A PoultsidesShishir K MaithelHugo P MarquesGuillaume MartelCarlo PulitanoFeng ShenFrançois ChaucyBas Groot KoerkampItaru EndoKazunari SasakiFederico AucejoXu-Feng ZhangHua ZhuTimothy M Pawlik

Published in: Annals of surgical oncology (2024)

Early-onset ICC has distinct clinical and genomic/transcriptomic features. Morphologic and clinicopathologic characteristics were unable to fully explain differences in outcomes among early versus typical onset ICC patients. The current study offers a preliminary landscape of the molecular features of early-onset ICC.

Keyphrases

early onset
late onset
end stage renal disease
single cell
ejection fraction
chronic kidney disease
newly diagnosed
copy number
rna seq
peritoneal dialysis
prostate cancer
gene expression
rectal cancer
skeletal muscle
metabolic syndrome
genome wide
single molecule
patient reported