Early Adaptation of Colorectal Cancer Cells to the Peritoneal Cavity Is Associated with Activation of "Stemness" Programs and Local Inflammation.
Jorge BarriusoRaghavendar T NagarajuShreya BelgamwarBipasha ChakrabartyGeorge J BurghelHelene SchlechtLucy FosterElaine KilgourAndrew J WallaceMichael BraunCaroline DiveDafydd Gareth EvansRobert G BristowMark P SaundersSarah T O'DwyerOmer AzizPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
Our findings indicated that the activation of "stemness" pathways and adaptation to the peritoneal-specific environment are key to early stages of peritoneal carcinomatosis. The in silico analysis suggested that this 20-gene peritoneal signature may hold prognostic information with potential for development of new precision medicine strategies in this setting.