SCN5A mutation status increases the risk of major arrhythmic events in Asian populations with Brugada syndrome: systematic review and meta-analysis.

Pattara RattanawongJirat ChenbhanichPoemlarp MekraksakitWasawat Vutthikraivit Pakawat ChongsathidkietNath LimpruttidhamNarut PrasitlumkumEugene H Chung

Published in: Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc (2018)

SCN5A mutations in BrS increase the risk of MAE in Asian populations, symptomatic BrS patients, and individuals with spontaneous type-1 Brugada pattern. Our study suggests that SCN5A mutation status should be an important tool for risk assessment in BrS patients.

Keyphrases

end stage renal disease
risk assessment
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
climate change
genetic diversity