Annexin A3 is necessary for parallel artery-vein alignment in the mouse retina.

Katie HuangAngela M CristNehal R PatelAvery BlanksKelsey CarterOndine CleaverStryder M Meadows

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2020)

Anxa3 is not essential for embryonic blood vessel formation but is required for proper parallel AV alignment in the murine retina. AV crossovers associated with Anxa3f/f ;Tie2-Cre mice are similar to AV intersections observed in patients with branch retinal vein occlusion (BRVO), although we did not observe occluded vessels. This new Anxa3 mouse model may provide a basis for understanding AV crossover formation associated with BRVO.

Keyphrases

diabetic retinopathy
mouse model
optic nerve
optical coherence tomography
high fat diet induced
type diabetes
open label
clinical trial
metabolic syndrome
skeletal muscle
adipose tissue