Toward the Scalable Fabrication of Fully Bio-Based Antimicrobial and UVB-Blocking Transparent Polylactic Acid Films That Incorporate Natural Coatings and Nanopatterns.

Microbial transmissions via membrane surface and single-use plastic-induced pollution are two urgent societal problems. This research introduces a scalable fabrication strategy for fully biobased antibacterial and ultraviolet-B block polylactic acid (PLA) films integrating natural coatings and nanopatterns via ultrasonic atomization spray coating and thermal nanoimprinting lithography (TNIL) techniques, respectively. Tannic acid (TA) and gallic acid (GA) were formulated prior to TNIL using anode aluminum oxide template. Results reveal that TA and GA inks display intense adsorption in the UVB region. Plasma increases the hydrophilicity of PLA films for fast spreading of ink droplets. Micron-sized pillars observed on film confirm the successful structural replication. TA-coated PLA films display higher transparency than GA-coated ones. Nanopatterned PLA films have a modest antibacterial resistance of c. 45% against Escherichia coli . TA/GA coatings, however, impart PLA films with a bacterial reduction rate of over 80%. The integration of a TA or GA coating with nanopatterns further promotes the antibacterial rate up to 98%. The cytocompatibility of TA and GA demonstrates that the engineered film can potentially be applied as food packaging. Finally, a continuous mass production strategy is proposed along with an outline of the associated challenges and costs. This study provides a scalable strategy to the sustainable development of eco-benign and functional films.