Effects of Dexmedetomidine Postconditioning on Myocardial Ischemia/Reperfusion Injury in Diabetic Rats: Role of the PI3K/Akt-Dependent Signaling Pathway.
Xiangyang ChengJing HuYa WangHongwei YeXiaohong LiQin GaoZhenghong LiPublished in: Journal of diabetes research (2018)
The results of this study suggest that DEX postconditioning may increase the phosphorylation of GSK-3β by activating the PI3K/Akt signaling pathway and may inhibit apoptosis and oxidative stress of the myocardium, thus exerting protective effects in diabetic rat hearts suffering from I/R injury.
Keyphrases
- oxidative stress
- signaling pathway
- diabetic rats
- ischemia reperfusion injury
- pi k akt
- induced apoptosis
- epithelial mesenchymal transition
- cell cycle arrest
- dna damage
- type diabetes
- left ventricular
- endoplasmic reticulum stress
- cerebral ischemia
- cell proliferation
- protein kinase
- heart failure
- heat shock protein
- blood brain barrier