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Cytotoxicity and Antitumor Activity of Arglabin and its Derivatives.

Sergazy M AdekenovVojtech SpiwokJohn A A BeutlerOlga MaslovaKayrolla Dyusenbaevich Rakhimov
Published in: Open access Macedonian journal of medical sciences (2023)
When studying the antitumor activity on 60 cell lines of tumor cells (NCI60), clonogenic cells of C6 rat glioma, a high antitumor activity of some arglabin derivatives was established. The connection between the structure of arglabin derivatives and their inhibitory effect on farnesyl protein transferase, topoisomerases -I and -II was studied.
Keyphrases
  • induced apoptosis
  • structure activity relationship
  • oxidative stress
  • cell cycle arrest
  • protein protein
  • amino acid
  • small molecule
  • pi k akt