Immunomodulation by juglone alleviates acute graft-versus-host disease without compromising the graft-versus-leukaemia activity in mice.

Dievya GohilKhushboo A GandhiSaurabh Kumar GuptaPoonam GeraSubhash YadavRaghavendra PatwardhanRahul CheckerDeepak SharmaNavin KhattrySantosh SandurVikram Gota

Published in: British journal of pharmacology (2024)

Juglone is a potent immunomodulator for GVHD prophylaxis. Our study is the first to provide a dosage framework for the oral administration of juglone that can be used for clinical development.

Keyphrases

liver failure
respiratory failure
high fat diet induced
drug induced
type diabetes
mouse model
adipose tissue
metabolic syndrome
aortic dissection
intensive care unit
skeletal muscle
wild type