Neoadjuvant Therapy Remodels the Pancreatic Cancer Microenvironment via Depletion of Protumorigenic Immune Cells.

Carmen Mota ReyesSteffen TellerAlexander MuckenhuberBjörn KonukiewitzOkan SafakWilko WeichertHelmut FriessGüralp O CeyhanIhsan Ekin Demir

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

NeoTx is not only cytotoxic but has pleiotropic, beneficial effects on all cellular and noncellular components of pancreatic cancer. Combinational approaches including immunotherapy may unleash long-term and more effective antitumor responses and improve prognosis of pancreatic cancer.

Keyphrases

stem cells
rectal cancer
lymph node
locally advanced
squamous cell carcinoma
mesenchymal stem cells
smoking cessation