MiR-130a is aberrantly overexpressed in adult acute myeloid leukemia with t(8;21) and its suppression induces AML cell death.
Chao DingSu-Ning ChenRoderick A F MacleodHans G DrexlerStefan NagelDe-Pei WuAi-Ning SunHai-Ping DaiPublished in: Upsala journal of medical sciences (2018)
Our data suggest that miR-130a is directly activated by AML1/ETO, and may act as a factor which is associated with leukemia burden, event-free survival, and chemotherapy sensitivity in t(8;21) AML.
Keyphrases
- acute myeloid leukemia
- free survival
- cell proliferation
- cell death
- long non coding rna
- allogeneic hematopoietic stem cell transplantation
- long noncoding rna
- locally advanced
- big data
- risk factors
- radiation therapy
- acute lymphoblastic leukemia
- cell cycle arrest
- bone marrow
- signaling pathway
- artificial intelligence
- rectal cancer
- data analysis