Diet differentially regulates enterochromaffin cell serotonin content, density and nutrient sensitivity in the mouse small and large intestine.

Martin M AlyceLauren A JonesClaire F JessupEmily W SunDamien J Keating

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2020)

Our findings from this study add novel insights into the mechanisms by which functional changes to EC cells occur at a cellular level, which may contribute to the altered circulating 5-HT seen with obesity and metabolic disease, and associated gastrointestinal disorders.

Keyphrases

weight loss
induced apoptosis
metabolic syndrome
insulin resistance
type diabetes
single cell
physical activity
cell therapy
high fat diet induced
oxidative stress
cell death
body mass index
bone marrow
cell proliferation
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