Methylthioadenosine Phosphorylase Genomic Loss in Advanced Gastrointestinal Cancers.

Natalie Yan Li Ngoi Tin-Yun TangCatia F GasparDean C PavlickGregory M BucholdEmma L ScholefieldVamsi ParimiRichard S P HuangTyler JanovitzNatalie DanzigerMia A LevyShubham PantAnaemy Danner De ArmasDavid KumpulaJeffery S Ross Milind M Javle Jordi Rodon Ahnert

Published in: The oncologist (2024)

In GI cancers, MTAP-loss occurs as part of 9p21 loss and has an overall prevalence of 8%. MTAP-loss occurs in 22% of PDAC, 15% of IHCC, 8.7% of gastroesophageal adenocarcinoma, 2.4% of hepatocellular carcinoma, and 1.1% of CRC and is not mutually exclusive with other targetable mutations.

Keyphrases

risk factors
gene expression
radiation therapy
young adults
dna methylation