The Relationship of Duffy Gene Polymorphism, High Sensitivity C-Reactive Protein, and Long-term Outcomes.
Edward T HaKent D TaylorLaura M RaffieldMatt BriggsAaron YeeOlivier ElementoManish ParikhStephen J PetersonWilliam FrishmanRobert E GersztenJames G WilsonKarl T KelseyUsman A TahirAlexander P ReinerPaul AuerTeresa SeemanStephen S RichApril P CarsonWendy S PostJerome I RotterWilbert S AronowPublished in: medRxiv : the preprint server for health sciences (2023)
These findings suggest that increased levels of hs-CRP found in Duffy null individuals is due to co-inheritance of CRP alleles known to influence circulating levels hs-CRP and that Duffy null status was not associated with worse adverse outcomes over the follow-up period in this cohort of well-balanced Black participants.