Role of germline aberrations affecting CTNNA1, MAP3K6 and MYD88 in gastric cancer susceptibility.

Robbert D A WerenRachel S van der PostIngrid P VogelaarJ Han van KriekenLiesbeth SpruijtJan LubinskiAnna JakubowskaUrszula TeodorczykCora M AalfsLiselotte P van HestCarla OliveiraEveline J KampingHans K SchackertGuglielmina N RanzaniEncarna B Gómez GarcíaFrederik J HesElke Holinski-FederMaurizio GenuardiMargreet G E M AusemsRolf H SijmonsAnja WagnerLizet E van der KolkAnnemieke CatsInga BjørnevollNicoline HoogerbruggeMarjolijn J L Ligtenberg

Published in: Journal of medical genetics (2018)

Based on our results MAP3K6 should no longer be considered a GC predisposition gene, whereas deleterious CTNNA1 variants are confirmed as an infrequent cause of GC susceptibility. Biallelic MYD88 germline mutations are at most a very rare cause of GC susceptibility as no additional cases were identified.

Keyphrases

copy number
toll like receptor
gas chromatography
dna repair
genome wide
gene expression
dna methylation
immune response
dna damage
transcription factor