Role of germline aberrations affecting CTNNA1, MAP3K6 and MYD88 in gastric cancer susceptibility.
Robbert D A WerenRachel S van der PostIngrid P VogelaarJ Han van KriekenLiesbeth SpruijtJan LubinskiAnna JakubowskaUrszula TeodorczykCora M AalfsLiselotte P van HestCarla OliveiraEveline J KampingHans K SchackertGuglielmina N RanzaniEncarna B Gómez GarcíaFrederik J HesElke Holinski-FederMaurizio GenuardiMargreet G E M AusemsRolf H SijmonsAnja WagnerLizet E van der KolkAnnemieke CatsInga BjørnevollNicoline HoogerbruggeMarjolijn J L LigtenbergPublished in: Journal of medical genetics (2018)
Based on our results MAP3K6 should no longer be considered a GC predisposition gene, whereas deleterious CTNNA1 variants are confirmed as an infrequent cause of GC susceptibility. Biallelic MYD88 germline mutations are at most a very rare cause of GC susceptibility as no additional cases were identified.