Genome-Wide Association Study of Body Weight Traits in Chinese Fine-Wool Sheep.
Zengkui LuYaojing YueChao YuanJianbin LiuZhiqiang ChenChune NiuXiaoping SunShaohua ZhuHongchang ZhaoTingting GuoBohui YangPublished in: Animals : an open access journal from MDPI (2020)
Body weight is an important economic trait for sheep and it is vital for their successful production and breeding. Therefore, identifying the genomic regions and biological pathways that contribute to understanding variability in body weight traits is significant for selection purposes. In this study, the genome-wide associations of birth, weaning, yearling, and adult weights of 460 fine-wool sheep were determined using resequencing technology. The results showed that 113 single nucleotide polymorphisms (SNPs) reached the genome-wide significance levels for the four body weight traits and 30 genes were annotated effectively, including AADACL3, VGF, NPC1, and SERPINA12. The genes annotated by these SNPs significantly enriched 78 gene ontology terms and 25 signaling pathways, and were found to mainly participate in skeletal muscle development and lipid metabolism. These genes can be used as candidate genes for body weight in sheep, and provide useful information for the production and genomic selection of Chinese fine-wool sheep.
Keyphrases
- body weight
- genome wide
- copy number
- dna methylation
- skeletal muscle
- air pollution
- genome wide association study
- healthcare
- cell proliferation
- metabolic syndrome
- type diabetes
- adipose tissue
- young adults
- mechanical ventilation
- oxidative stress
- transcription factor
- genome wide identification
- health information
- social media
- pi k akt
- endoplasmic reticulum stress
- induced apoptosis
- life cycle