Systemic chemotherapy of pediatric recurrent ependymomas: results from the German HIT-REZ studies.
Jonas E AdolphGudrun FleischhackChristine GaabRuth MikaschMartin MynarekStefan RutkowskiUlrich SchüllerStefan M PfisterKristian W PajtlerTill MildeOlaf WittBrigitte BisonMonika Warmuth-MetzRolf-Dieter KortmannStefan DietzschTorsten PietschBeate TimmermannStephan Tippeltnull nullPublished in: Journal of neuro-oncology (2021)
No survival advantage for the general use of chemotherapy in recurrent EPN was found. In cases with incomplete resection, chemotherapy was able to extend survival in individual cases. Sirolimus showed the best RR, DOR and TTP out of all drugs analyzed and may warrant further investigation.