Spine eburnation in a metastatic lung cancer patient treated with immunotherapy and radiotherapy. The first case report of bystander effect on bone.

Silvana ParisiIlenia NapoliSara LilloAlberto CacciolaGianluca FeriniGiuseppe IatìAntonio PontorieroConsuelo TamburellaValerio DavìStefano Pergolizzi

Published in: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners (2021)

The present case alerts for unusual side effects provoked by bystander phenomenon in patients treated with a combination of immunotherapy and irradiation. Immune activation exacerbates the bystander effect causing normal tissues toxicities beyond what immunotherapies are causing by themselves.

Keyphrases

case report
squamous cell carcinoma
small cell lung cancer
early stage
gene expression
radiation therapy
locally advanced
bone mineral density
rectal cancer