Exploring the Genetic Architecture of Spontaneous Coronary Artery Dissection Using Whole-Genome Sequencing.

Ingrid S Tarr Stephanie E Hesselson Siiri E Iismaa Emma M Rath Steven Monger Michael Troup Ketan Mishra Claire M Y Wong Pei-Chen Hsu Keerat Junday David T Humphreys David Adlam Thomas R Webb Ania A Baranowska Stephen E Hamby Keren Jacqueline Carss Nilesh J Samani Monique BaxLucy McGrath-CadellJason C Kovacic Sally L Dunwoodie Diane Fatkin David W M Muller Robert M Graham Eleni Giannoulatou

Published in: Circulation. Genomic and precision medicine (2022)

SCAD shares some genetic overlap with CTD, even in the absence of any major CTD phenotype. Consistent with a complex genetic architecture, SCAD patients also have a higher burden of common variants than controls.

Keyphrases

coronary artery
copy number
genome wide
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
pulmonary artery
peritoneal dialysis
prognostic factors
gene expression
dna methylation
patient reported outcomes