Clonal Relatedness and Mutational Differences between Upper Tract and Bladder Urothelial Carcinoma.
Francois AudenetSumit IsharwalEugene K ChaMark T A DonoghueEsther N DrillIrina OstrovnayaEugene J PietzakJohn P SfakianosAditya BagrodiaPaari MuruganGuido DalbagniTimothy F DonahueJonathan E RosenbergDean F BajorinMaria E ArcilaJaclyn F HechtmanMichael F BergerBarry S TaylorHikmat Al-AhmadieGopa IyerBernard H BochnerJonathan A ColemanDavid B SolitPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
UTUC and UCB exhibit significant differences in the prevalence of common genomic alterations. In individual patients with a history of both tumors, UCB and UTUC were always clonally related. Genomic characterization of UTUC provides information regarding the risk of bladder recurrence and can identify tumors associated with Lynch syndrome.