Immunocompromised rabbit model of chronic HEV reveals liver fibrosis and distinct efficacy of different vaccination strategies.

Qiyu HeFan ZhangJingyi ShuShuangshuang LiZhaochao LiangMinghao DuXing LiuTianxu LiuManyu LiXin YinMaikel P PeppelenboschFengmin LuLing WangLin Wang

Published in: Hepatology (Baltimore, Md.) (2022)

The immunocompromised rabbit model of both chronic HEV3 and HEV4 infection that was established captured the key features of chronic HEV infection in transplant patients, including liver fibrogenesis, and revealed the distinct effectiveness of vaccination administered before or under immunosuppression. This rabbit model is valuable for understanding the pathogenesis of chronic hepatitis E, as well as for evaluating antiviral agents and vaccines.

Keyphrases

liver fibrosis
end stage renal disease
chronic kidney disease
systematic review
ejection fraction
prognostic factors
peritoneal dialysis
intensive care unit