Sacubitril/valsartan protective effect on induced intestinal ischemia/reperfusion injury via immune modulation of IL6/STAT1 pathway.

Marwa Monier Mahmoud Refaie Entesar Farghly Amin Marwa Nadi Hassan Rehab Ahmed Rifaai Asmaa M A Bayoumi Maha Yehia Kamel

Published in: The Journal of pharmacy and pharmacology (2024)

SAC/VAL prevents IIR-induced damage via modulation of renin angiotensin aldosterone system, antioxidant, anti-apoptotic, anti-inflammatory properties, and regulation of IL6/STAT1 pathway.

Keyphrases

anti inflammatory
oxidative stress
diabetic rats
ischemia reperfusion injury
high glucose
cell proliferation
drug induced
cell death
angiotensin converting enzyme
endothelial cells
ejection fraction
mouse model