Rational Design, Structure-Activity Relationship, and Immunogenicity of Hypoallergenic Pru p 3 Variants.

Stephanie EichhornAngelika HörschlägerMarkus SteinerJosef LaimerBettina M JensenSerge A VersteegIsabel PablosPeter BrizaLaurian JongejanNeil RigbyJuan A AsturiasAntonio PortolésMontserrat Fernandez-RivasNikolaos G PapadopoulosAdriano MariLars K PoulsenPeter LacknerRonald van ReeFatima FerreiraGabriele Gadermaier

Published in: Molecular nutrition & food research (2019)

An in silico approach is used to generate a PV without targeting disulfide bonds, T cell epitopes, or previously reported IgE epitopes of Pru p 3. PV is strongly hypoallergenic while structurally stable and immunogenic, thus representing a promising candidate for peach allergen immunotherapy.

Keyphrases

structure activity relationship
copy number
molecular docking
cancer therapy
gene expression
drug delivery
dna methylation