Hepatoprotective effects of vicenin-2 and scolymoside through the modulation of inflammatory pathways.
In-Chul LeeJong Sup BaePublished in: Journal of natural medicines (2019)
The aim of this study was to investigate the effects of two structurally related flavonoids found in Cyclopia subternata, vicenin-2 (VCN) and scolymoside (SCL) on lipopolysaccharide (LPS)-induced liver failure in mice and to elucidate underlying mechanisms. Mice were treated intravenously with VCN or SCL at 12 h after LPS treatment. LPS significantly increased mortality, serum levels of alanine transaminase, aspartate transaminase, and inflammatory cytokines, and toll-like receptor 4 (TLR4) protein expression; these effects of LPS were inhibited by VCN or SCL. It also attenuated the LPS-induced activation of myeloid differentiation primary response gene 88 and TLR-associated activator of interferon-dependent signaling pathways of the TLR system. Our results suggest that VCN or SCL protects against LPS-induced liver damage by inhibiting the TLR-mediated inflammatory pathway, indicating its potential to treat liver diseases.
Keyphrases
- inflammatory response
- lps induced
- toll like receptor
- nuclear factor
- liver failure
- signaling pathway
- oxidative stress
- dendritic cells
- hepatitis b virus
- high fat diet induced
- bone marrow
- acute myeloid leukemia
- type diabetes
- copy number
- cardiovascular events
- genome wide
- risk factors
- epithelial mesenchymal transition
- combination therapy
- induced apoptosis
- smoking cessation