Urine Cell-Free Mitochondrial DNA as a Marker of Weight Loss and Body Composition in Older Adults With HIV.
Carrie D JohnstonEugenia L SieglerMichelle C RiceHeather M DerryKatie C HootmanYuan-Shan ZhuChelsie O BurchettSamir K GuptaMary E ChoiMarshall J GlesbyPublished in: Journal of acquired immune deficiency syndromes (1999) (2021)
In this cross-sectional study of OAH, higher levels of urine cfmtDNA were more common in subjects with less robust physical condition, including unintentional weight loss and less height-scaled body mass of fat and muscle. These findings suggest urine cfmtDNA may reflect pathophysiologic aging processes in OAH, predisposing them to geriatric syndromes. Longitudinal investigation of urine cfmtDNA as a biomarker of geriatric syndromes is warranted.
Keyphrases
- body composition
- weight loss
- mitochondrial dna
- cell free
- bariatric surgery
- copy number
- physical activity
- resistance training
- bone mineral density
- antiretroviral therapy
- adipose tissue
- human immunodeficiency virus
- body mass index
- gastric bypass
- hiv infected
- mental health
- metabolic syndrome
- hiv aids
- gene expression
- type diabetes
- hiv testing
- men who have sex with men
- circulating tumor
- circulating tumor cells