mTOR Signaling: New Insights into Cancer, Cardiovascular Diseases, Diabetes and Aging.
Anindita DasFlávio ReisPublished in: International journal of molecular sciences (2023)
The mechanistic/mammalian target of rapamycin (mTOR), a member of the phosphoinositide 3-kinase (PI3K) related kinase family, integrates intracellular and environmental cues that coordinate a diverse set of cellular/tissue functions, such as cell growth, proliferation, metabolism, autophagy, apoptosis, longevity, protein/lipid/nucleotide synthesis, and tissue regeneration and repair [...].
Keyphrases
- cardiovascular disease
- endoplasmic reticulum stress
- oxidative stress
- cell death
- signaling pathway
- cell proliferation
- type diabetes
- stem cells
- protein kinase
- papillary thyroid
- tyrosine kinase
- cell cycle arrest
- squamous cell
- adipose tissue
- human health
- amino acid
- metabolic syndrome
- lymph node metastasis
- reactive oxygen species
- climate change
- drug induced