Big conductance calcium-activated potassium channel openers control spasticity without sedation.

David BakerGareth PryceCristina VisintinSofia SisayAlexander I BondarenkoW S Vanessa HoSamuel J JacksonThomas E WilliamsSarah Al-IzkiIoanna SevastouMasahiro OkuyamaWolfgang F GraierLesley A StevensonCarolyn TannerRuth RossRoger G PertweeChristopher M HenstridgeAndrew J IrvingJesse SchulmanKeith PowellMark D BakerGavin GiovannoniDavid L Selwood

Published in: British journal of pharmacology (2017)

We identified the neuronal form of the BKCa channel as the target for VSN16R and demonstrated that its activation alleviates neuronal excitability and spasticity in an experimental model of MS, revealing a novel mechanism to control spasticity. VSN16R is a potential, safe and selective ligand for controlling neural hyper-excitability in spasticity.

Keyphrases

botulinum toxin
spinal cord injury
upper limb
cerebral palsy
children with cerebral palsy
transcranial direct current stimulation
mass spectrometry
multiple sclerosis
machine learning
intensive care unit
risk assessment
mechanical ventilation
mouse model
brain injury
deep learning