Long-term survival follow-up for tebentafusp in previously treated metastatic uveal melanoma.
Joseph J SaccoRichard D CarvajalMarcus O ButlerAlexander N ShoushtariJessica C HasselAlexandra IkeguchiLeonel Hernandez-AyaPaul NathanOmid HamidJosep M PiulatsMatthew RiothDouglas B JohnsonJason John LukeEnrique EspinosaSerge LeyvrazLaura CollinsChris HollandTakami SatoPublished in: Journal for immunotherapy of cancer (2024)
This study represents the longest follow-up of a Tcell receptor bispecific to date and confirms the durable survival benefits achieved with tebentafusp in previously treated mUM with good tolerability long-term. A role for ctDNA reduction as an early indicator of clinical benefit was again suggested for patients treated with tebentafusp.