The Immune Microenvironment and Neoantigen Landscape of Aggressive Salivary Gland Carcinomas Differ by Subtype.

Maximilian LinxweilerFengshen KuoNora KatabiMark LeeZaineb NadeemMartin G DalinVladimir MakarovDiego ChowellSnjezana DoganIan GanlyA Ari HakimiRichard J WongNadeem RiazAlan L HoTimothy A ChanLuc G T Morris

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

These findings provide new insights into the immune microenvironment and neoantigen landscape of SGCs, showing that mechanisms of immune escape appear to differ by histology. These data nominate potential immunologic vulnerabilities and may help guide the next steps of investigation in precision immunotherapy for these difficult-to-treat cancers.

Keyphrases

stem cells
electronic health record
high grade
climate change
human health
deep learning
artificial intelligence
childhood cancer