Small airway determinants of airflow limitation in chronic obstructive pulmonary disease.
Vasiliy V PolosukhinSergey S GutorRui-Hong DuBradley W RichmondPierre P MassionPingsheng WuJustin M CatesKim L SandlerStephen I RennardTimothy S BlackwellPublished in: Thorax (2021)
In COPD, loss of radial alveolar attachments in small airways is the pathological feature most closely related to airflow limitation. Destruction of alveolar attachments may be mediated by neutrophilic inflammation.